MESO PIGMENT REDUCE (30 ml)

The treatment addresses

Fast brightening effect

• Reduces the visibility of uneven skin tone and pigment build‑up by effectively inhibiting melanin synthesis. Delivers a more even, light‑reflecting skin surface after just a few sessions.

Hyperpigmentation

• Targets both superficial and deeper pigment changes, including sun damage and post‑inflammatory hyperpigmentation. Works by regulating melanocyte activity and improving the skin’s natural regeneration.

Age spots (lentigines)

• Reduces age‑related dark spots through a combination of brightening actives and cell‑renewing mechanisms. The result is a more even tone with reduced contrast between the spot and surrounding skin.

Dark circles under the eyes

• Acts on both vascular and pigmented dark circles. Improves microcirculation, reduces melanin build‑up and strengthens periorbital skin structure for a fresher, more rested look.

Treatment areas

Face:

• Treats pigmentary disorders such as melasma, sun damage and dark circles.
• Evens out skin tone and lightens dark spots for a more uniform, radiant complexion.
• Supports anti‑age benefits by stimulating natural cell renewal and improving firmness and elasticity.

Body:

• Suited to areas exposed to sun damage and uneven pigmentation, e.g., neck, décolletage, arms and legs.
• Reduces and helps prevent dark spots for a smoother, more even tone.
• Moisturising and nourishing ingredients strengthen the barrier, supporting smoother, more youthful‑looking skin.

Hands:

• Effective against age spots, uneven pigmentation and dryness on the hands.
• Helps brighten and even the appearance of the hands for a younger, well‑groomed look.

Anti‑age benefits:

• Cell‑renewing, moisturising and nourishing ingredients help reduce the appearance of fine lines and wrinkles.
• Antioxidants and collagen‑stimulating agents support elasticity and firmness, resulting in a more youthful skin structure.

Effect on dark spots:

• Meso Pigment Reduce contains brightening, melanin‑regulating actives that target and help prevent hyperpigmentation, melasma, age spots and dark circles.
• With continued use, the complexion appears clearer, more even and free from visible pigment changes.

Active ingredients

Glabridin (from licorice root)

• Function: Brightening; inhibits melanin production; anti‑inflammatory.

• Effect: Reduces discolorations and promotes a more even skin tone.

Kojic Acid (from rice‑wine fermentation)

• Function: Inhibits tyrosinase and melanin production.

• Effect: Lightens dark spots and uneven tone for clearer skin.

Arbutin (Alpha‑Arbutin) (from berries and bearberry)

• Function: Inhibits tyrosinase and reduces melanin.

• Effect: Lightens dark spots and promotes a more uniform complexion.

Azelaic Acid (Azelamide MEA) (synthetic derivative from cereal sources)

• Function: Anti‑inflammatory; inhibits melanin; reduces redness.

• Effect: Decreases hyperpigmentation and uneven tone with a mild smoothing action.

Vitamin C (3‑O‑Ethyl Ascorbic Acid) (stable derivative)

• Function: Antioxidant; protects from free radicals; stimulates collagen.

• Effect: Brightens skin, improves firmness and reduces pigment for a youthful glow.

Kudzu (Pueraria Lobata Root Extract) (from the kudzu root)

• Function: Antioxidant and soothing.

• Effect: Protects against signs of ageing and supports an even skin tone.

Meso Pigment Reduce — targeted depigmentation

MESO PIGMENT REDUCE is an intense, effective and innovative treatment for hyperpigmentation, melasma, sun damage, age spots, discolorations and dark circles. It helps reduce and prevent spots on the face, body and hands.

Melanogenesis and unhealthy skin color

Skin color results from multiple pigments: haemoglobin in red blood cells and carotene in adipocytes. Most decisive is melanin, produced by melanocytes in the epidermis, which regulates skin color via complex mechanisms.

Unhealthy coloration is usually due to excess melanin or deposition of other pigments in the epidermis — locally or more widespread. Discolorations vary in origin and depth.
 

How to use

Apply the product twice daily directly to the area. Effects are typically visible after the first applications.
 

Key ingredients

Glabridin — isoflavonoid from Glycyrrhiza glabra root. In vitro/in vivo shows antioxidant, anti‑inflammatory, neuroprotective, antiteratogenic, antibacterial and depigmenting activity with topical use. The depigmenting effect is multifunctional and addresses several causes of unhealthy coloration.

Vitamin C (ascorbic acid) — reduces melanin production by reducing o‑DOPAchinone to DOPA and interrupting the oxidation process that forms melanin. The more stable profile enhances overall effect.

Arbutin — natural glucoside of hydroquinone (hydroquinone‑β‑D‑glucopyranoside). Studies on human melanocytes indicate a mechanism different from synthesis/enzyme expression. Clinical use without hydroquinone‑typical side effects.

Kojic acid — inhibits tyrosinase via copper chelation at the active site. Clinically documented depigmenting effect and safety. Inhibits MITF‑related transcription and α‑MSH‑stimulated melanogenesis.

Azelaic acid — depigmenting via competitive tyrosinase inhibition.

Niacinamide — biologically active amide of vitamin B3. Together with sun protection, clarity can improve more than with sun protection alone.

Vitamin A (retinoic acid) — depigmenting via increased keratinocyte turnover (epidermal pigment loss) and indirect cytotoxic effect on melanocytes by inhibiting detox pathways.

Pueraria (Kudzu) — root/flower used traditionally; multiple studies show inhibition of melanogenesis (confirmed by Fontana‑Masson staining).

Brassica napus seed extract — antioxidant‑rich; in vitro/in vivo shows reduction of discoloration and a more even tone.

Clinical study – reduction of age spots

• Participants: 15 healthy female subjects aged 45–76 years

• Protocol: Application twice daily for 4 weeks

• Treatment area: Forearm

• Method: Photo documentation and image quantification

Results:

• Documented increase in lightness of age spots after the treatment period

• Achromaxyl ISR biofunctional visibly reduced the appearance of age spots

• Regular use may help stabilise and maintain a more even skin tone

See the study here

Meso Pigment Reduce with documented depigmenting effect

Formulated with actives acting on multiple biological levels:

• Tyrosinase inhibition – reduces melanin biosynthesis.

• Chelating mechanisms – inhibit metal‑ion‑dependent steps in pigment formation.

• Antioxidant protection – counteracts oxidative stress that triggers hyperpigmentation.

• Regulation of melanogenesis – balances melanocyte activity.

• Increased epidermal turnover – promotes faster replacement of pigmented keratinocytes.

Clinical summary

Multifunctional depigmentation

• The combination of glabridin, kojic acid, arbutin, azelaic acid, vitamin C, niacinamide, retinoic acid, Pueraria extract and Brassica napus seed extract acts on multiple levels:

  • Inhibition of tyrosinase and other melanogenesis enzymes → reduced melanin production.

  • Chelating effect → binding of iron and copper, necessary cofactors in pigment formation.

  • Antioxidant protection → neutralises free radicals that stimulate hyperpigmentation.

  • Improved cell renewal → faster replacement of pigmented keratinocytes.

Targeted clinical indications

• Reduces visible hyperpigmentations (sun damage, melasma, post‑inflammatory spots).

• Treats age spots and uneven tone.

• Supports treatment of dark circles in the periorbital area.

Tone stabilisation

• The actives provide both short‑term brightening and long‑term stabilisation of an even tone.

• Helps prevent recurrence by modulating melanocyte activity.

Synergy with anti‑age

• Retinoids and vitamin C stimulate collagen → improved firmness and elasticity.

• Antioxidants and vitamins reduce oxidative stress that accelerates ageing.

• Moisture‑binding components (e.g., niacinamide and botanical extracts) support hydration and barrier protection.

Overall clinical effect

• More even, smooth and luminous skin surface.

• Reduction of dark spots and signs of ageing.

• Improved skin texture and strengthened barrier function.

Ingredients (INCI)

• Glycerin – Moisturising humectant; binds water and supports elasticity.

• Niacinamide (B3) – Strengthens barrier; reduces pigment and fine lines.

• Dicaprylyl Ether – Emollient; improves texture.

• Stearic Acid – Thickener and emulsifier; stabilises the formula.

• Ethoxydiglycol – Enhances penetration of actives.

• Cera Alba (Beeswax) – Protects; helps retain moisture.

• Cetearyl Alcohol – Emollient; stabilising.

• Caprylic/Capric Triglyceride – Lightweight emollient; moisturising.

• Polyglyceryl‑6 Distearate & Polyglyceryl‑3 Beeswax – Emulsifiers for a smooth texture.

• Titanium Dioxide – UV protection; brightening effect.

• Thioctic Acid (Alpha‑Lipoic Acid) – Antioxidant; counteracts oxidative stress.

• Hydrolyzed Brassica Napus Seedcake Extract – Conditioning; skin‑care benefits.

• Retinyl Palmitate (Vitamin A) – Promotes renewal and collagen; reduces lines.

• Tocopheryl Acetate (Vitamin E) – Antioxidant; protects against signs of ageing.

• Jojoba Esters – Moisturising; softening.

• Dimethicone – Provides slip; seals in moisture.

• Phenethyl Alcohol, Caprylyl Glycol – Preservation; mild moisturising.

• Cetyl Alcohol – Emulsifier; moisture retention.

• Acrylates/C10‑30 Alkyl Acrylate Crosspolymer – Thickener; stabiliser.

• Disodium EDTA – Chelator; improves shelf life.

• Triethanolamine – pH adjuster.

• Triethoxycaprylylsilane – Binder; improves texture.

• Sodium Benzoate, Potassium Sorbate – Preservatives; inhibit microbial growth.

• BHT, BHA – Antioxidants; protect against oxidation.

Active ingredients (relevant for anti‑age and dark spots):

Glabridin: Extracted from licorice root (Glycyrrhiza glabra).

• Function: Brightening; dampens melanin production; anti‑inflammatory.
• Effect on anti‑age/pigment: May help reduce discolorations and promote a more even tone.

Kojic Acid: Often produced by fermentation of rice wine (sake).

• Function: Inhibits tyrosinase, the enzyme responsible for melanin production.
• Effect on anti‑age/pigment: Lightens dark spots and uneven tone for a clearer, more even complexion.

Arbutin (Alpha‑Arbutin): Derived from plants such as berries (e.g., cranberries, blueberries) and bearberry.

• Function: Inhibits tyrosinase; reduces melanin production.
• Effect on anti‑age/pigment: Lightens dark spots and promotes a more uniform skin colour, reducing the visibility of spots.

Azelaic Acid (Azelamide MEA): Azelaic acid occurs naturally in cereals such as wheat, rye and barley; Azelamide MEA is a synthetic derivative.

• Function: Anti‑inflammatory; inhibits melanin production; can reduce redness.
• Effect on anti‑age/pigment: May reduce hyperpigmentation and uneven tone with a mild smoothing effect.

Vitamin C (3‑O‑Ethyl Ascorbic Acid): Stable vitamin‑C derivative.

• Function: Antioxidant; protects against free radicals; supports collagen production.
• Effect on anti‑age/pigment: May brighten, improve firmness and reduce dark spots, contributing to a youthful glow.

Kudzu (Pueraria Lobata Root Extract): Extracted from the kudzu root, an Asian plant.

• Function: Antioxidant and soothing effects on the skin.
• Effect on anti‑age/pigment: Helps protect against signs of ageing and may support a more even tone.